2. Signaling Pathways
  3. PROTAC
  4. Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Target Protein Ligand-Linker Conjugates

Related Products

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Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.

The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

Target Protein Ligand-Linker Conjugates Related Products (63):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-176787
    KRAS G12C Ligand-Linker Conjugates 1 3033236-98-2
    KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRASG12C ligand and linker, which can be used in the synthesis of PROTAC YF135 (HY-144323).
    KRAS G12C Ligand-Linker Conjugates 1
  • HY-172266
    FKBP12 Ligand-Linker Conjugate 2
    FKBP12 Ligand-Linker Conjugate 2 is a conjugate of the FKBP12 target protein ligand and a linker, and it can be used for the synthesis of FKBP12 PROTAC FM4 (HY-172265).
    FKBP12 Ligand-Linker Conjugate 2
  • HY-139403
    MRTX849 ethoxypropanoic acid 2561529-98-2
    MRTX849 ethoxypropanoic acid incorporates a ligand for KRAS G12C, and a PROTAC linker. MRTX849 ethoxypropanoic acid can be used in the synthesis of PROTAC LC-2 (HY-137516). LC-2 is a potent and first-in-class PROTAC capable of degrading endogenous KRAS G12C (IC50s between 0.25 and 0.76 μM).
    MRTX849 ethoxypropanoic acid
  • HY-175528
    ALK ligand-Linker Conjugate 1 2796974-34-8
    ALK ligand-Linker Conjugate 1 is a ALK ligand-linker conjugate that can be used for synthesis of PROTAC ALK degrader-4 (HY-175527).
    ALK ligand-Linker Conjugate 1
  • HY-176385
    3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid 2230826-10-3
    3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid is a target protein ligand-linker conjugate that incorporates a ligand for c-Met (HY-451241) and a PROTAC linker (HY-W442078), which recruits E3 ligases. 3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid can be used in the synthesis of PROTACs, such as SJF-8240 (HY-123961).
    3-Fluoro-desmethyl-cabozantinib-C3-O-C3-PEG-acid
  • HY-173137
    KDM4 Ligand-Linker Conjugate 1
    KDM4 Ligand-Linker Conjugate 1 is a conjugate of a KDM4 target protein ligand and a linker, and can be used for the synthesis of PROTAC KDM4 degrader-1 (HY-173135).
    KDM4 Ligand-Linker Conjugate 1
  • HY-169488
    SMARCA2 ligand-12-3-methylazetidine
    SMARCA2 ligand-12-3-methylazetidin is a target protein ligand-linker conjugate that incorporates a ligand for SMARCA2 (HY-169487), and a PROTAC linker (HY-W052601), which recruit E3 ligases. SMARCA2 ligand-12-3-methylazetidin can be used to synthesize PROTAC SMARCA2 degrader-25 (HY-169276).
    SMARCA2 ligand-12-3-methylazetidine
  • HY-176791
    CDK12-Cyclin K Ligand-Linker Conjugates 1
    CDK12-Cyclin K Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK12-Cyclin K (HY-176790) and a PROTAC linker (HY-W244922), which recruits E3 ligases. CDK12-Cyclin K Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC PP-C8 (HY-144691).
    CDK12-Cyclin K Ligand-Linker Conjugates 1
  • HY-175337
    c-Met ligand-Linker Conjugate 2 1103505-24-3
    c-Met ligand-Linker Conjugate 2 is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC c-Met degrader-6 (HY-175321). PROTAC c-Met degrader-6 is a c-Met PROTAC degrader with anti-tumor activity[1].
    c-Met ligand-Linker Conjugate 2
  • HY-176789
    VUBI1-octanoic acid
    VUBI1-octanoic acid is a conjugate of SOS1 ligand and linker, which can be used in the synthesis of (4S)-PROTAC SOS1 degrader-1 (HY-144657).
    VUBI1-octanoic acid
  • HY-153424
    PROTAC SMARCA2 degrader-1 2892523-73-6
    PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50<0.1 μM). PROTAC SMARCA2 degrader-1 is also an E3 ubiquitin ligase binding linker useful in research of cancers. PROTAC SMARCA2 degrader-1 is a target protein ligand-linker conjugate.
    PROTAC SMARCA2 degrader-1
  • HY-170769
    FLT3 Ligand-Linker Conjugate 1 2769753-49-1
    FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases.
    FLT3 Ligand-Linker Conjugate 1
  • HY-174995
    JQ-1-Azidopropylamine 2915642-70-3
    JQ-1-Azidopropylamine is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for BRD4 (HY-78695) and a PROTAC linker (HY-151862), which recruits E3 ligases. JQ-1-Azidopropylamine can be used for synthesis of PROTAC JY-21 (HY-174975).
    JQ-1-Azidopropylamine
  • HY-175255
    EGFR-IN-47-C6-COOMe
    EGFR-IN-47-C6-COOMe is a synthesized target protein ligand-linker conjugate that can be used for synthesis of PROTACs, such as PROTAC EGFR degrader 14 (HY-175252). PROTAC EGFR degrader 14 is a EGFR PROTAC degrader with anti-tumor activity.
    EGFR-IN-47-C6-COOMe
  • HY-176263
    TH10184-octanedioic acid
    TH10184-octanedioic acid is a conjugate of the NUDT5 ligand (HY-176262) and the linker (HY-W001958). TH10184-octanedioic acid can be used for synthesizing PROTAC NUDT5 degrader DDD2 (HY-176261).
    TH10184-octanedioic acid
  • HY-172126
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a ligand for BRD4, and a PROTACs linker that can be used in the synthesis of PROTAC BRD4 Degrader-29 (HY-172124).
    JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
  • HY-175193
    N-Deshydroxyethyl Dasatinib-C3-NH2 1430089-58-9
    N-Deshydroxyethyl Dasatinib-C3-NH2 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for LCK (HY-107447) and a PROTAC linker (HY-76667), which recruits E3 ligases. N-Deshydroxyethyl Dasatinib-C3-NH2 can be used for synthesis of PROTAC SJ11646 (HY-175281).
    N-Deshydroxyethyl Dasatinib-C3-NH2
  • HY-168458
    RNA recruiter-linker 1
    RNA recruiter-linker 1 is the RNA ligand-linker part of RNAse L RIBOTAC (HY-168455), an RNA-degrading chimera which binds to a four-way RNA helix called SL5 in the 5’ UTR of the SARS-CoV-2 RNA genome and inhibits the virus replication in lung epithelial carcinoma cells. RNA recruiter-linker 1 can be utilized in the synthesis of RIBOTAC.
    RNA recruiter-linker 1
  • HY-175374
    RIPK1 ligand-Linker Conjugate-1
    RIPK1 ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370).
    RIPK1 ligand-Linker Conjugate-1
  • HY-168693
    Target Protein Ligand-Linker Conjugates 2
    Target Protein Ligand-Linker Conjugates 2 is a conjugate of the Target Protein Ligand and Linker, consisting of Desmethyl-QCA276 (HY-44103) and the corresponding Linker. Target Protein Ligand-Linker Conjugates 2 can be used to synthesize PROTAC BD-9136 (HY-149878).
    Target Protein Ligand-Linker Conjugates 2